[Download] "Sparking Signals" by Gottfried Baier, Burkhart Schraven, Ulrich Zügel & Arne Bonin " eBook PDF Kindle ePub Free
eBook details
- Title: Sparking Signals
- Author : Gottfried Baier, Burkhart Schraven, Ulrich Zügel & Arne Bonin
- Release Date : January 19, 2008
- Genre: Pharmacology & Toxicology,Books,Professional & Technical,Medical,Science & Nature,Life Sciences,Immunology,
- Pages : * pages
- Size : 1869 KB
Description
Protein phosphorylation is an essential post-translational modification that modulates cell–cell communication. Substrate phosphorylation by protein kinases controls intracellular signal transduction pathways that mediate cell proliferation, migration, differentiation, and metabolism. The importance of the protein kinase family is underscored by numerous disease states that arise due to dysregulation of kinase activity. Recent progress in understanding the molecular regulation of kinases has led to the development of new therapeutics based on the inhibition of kinase activity. Inhibitors that target protein kinases have proven efficacious in clinical settings and their continued development is the current focus of many drug discovery groups.